Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2804404..2805029 Replicon chromosome
Accession NZ_CP107390
Organism Klebsiella pneumoniae strain CRKP_28

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH501_RS13865 Protein ID WP_002882817.1
Coordinates 2804646..2805029 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH501_RS13860 Protein ID WP_004150355.1
Coordinates 2804404..2804646 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH501_RS13835 2800395..2800994 + 600 WP_004151865.1 glucose-1-phosphatase -
OH501_RS13840 2800988..2801848 + 861 WP_002882807.1 virulence factor BrkB family protein -
OH501_RS13845 2801845..2802282 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH501_RS13850 2802327..2803268 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH501_RS13855 2803282..2804199 - 918 WP_002882812.1 alpha/beta hydrolase -
OH501_RS13860 2804404..2804646 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH501_RS13865 2804646..2805029 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH501_RS13870 2805203..2806132 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH501_RS13875 2806129..2806764 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH501_RS13880 2806761..2807663 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261047 WP_002882817.1 NZ_CP107390:2804646-2805029 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261047 WP_004150355.1 NZ_CP107390:2804404-2804646 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References