Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 77709..78352 Replicon plasmid unnamed1
Accession NZ_CP107373
Organism Klebsiella pneumoniae strain CRKP_31

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH494_RS27370 Protein ID WP_001044770.1
Coordinates 77709..78125 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH494_RS27375 Protein ID WP_001261282.1
Coordinates 78122..78352 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH494_RS27350 73812..74084 - 273 Protein_87 transposase -
OH494_RS27360 75066..76088 - 1023 WP_000361404.1 helicase UvrD -
OH494_RS27365 76073..77635 - 1563 WP_004206609.1 AAA family ATPase -
OH494_RS27370 77709..78125 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH494_RS27375 78122..78352 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH494_RS27380 78309..78725 + 417 WP_164481821.1 hypothetical protein -
OH494_RS27385 79270..80091 + 822 WP_004213562.1 hypothetical protein -
OH494_RS27390 80088..80867 + 780 WP_004213560.1 site-specific integrase -
OH494_RS27395 81012..81941 - 930 WP_004213558.1 Rpn family recombination-promoting nuclease/putative transposase -
OH494_RS27400 82245..82412 + 168 Protein_97 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..193835 193835
- inside IScluster/Tn - - 54660..74490 19830


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260979 WP_001044770.1 NZ_CP107373:c78125-77709 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260979 WP_001261282.1 NZ_CP107373:c78352-78122 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References