Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 801979..802456 Replicon chromosome
Accession NC_016912
Organism Staphylococcus aureus subsp. aureus VC40

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAVC_RS03910 Protein ID WP_000052078.1
Coordinates 801979..802167 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAVC_RS03915 Protein ID WP_001059690.1
Coordinates 802196..802456 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAVC_RS03880 798020..798490 + 471 WP_000824472.1 hypothetical protein -
SAVC_RS03885 798831..799517 + 687 WP_001548082.1 thermonuclease family protein -
SAVC_RS03890 799874..800074 + 201 WP_001059082.1 cold-shock protein -
SAVC_RS03895 800570..800788 - 219 WP_000005886.1 hypothetical protein -
SAVC_RS03900 800850..801134 - 285 WP_001004395.1 hypothetical protein -
SAVC_RS03905 801222..801791 - 570 WP_001106654.1 hypothetical protein -
SAVC_RS03910 801979..802167 - 189 WP_000052078.1 hypothetical protein Toxin
SAVC_RS03915 802196..802456 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAVC_RS03920 802797..803000 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAVC_RS03925 802997..803233 - 237 WP_000368687.1 hypothetical protein -
SAVC_RS03930 803458..804039 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAVC_RS03935 804112..804729 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAVC_RS03940 804884..805378 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAVC_RS03945 805777..806199 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAVC_RS03950 806347..807063 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T26095 WP_000052078.1 NC_016912:c802167-801979 [Staphylococcus aureus subsp. aureus VC40]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26095 NC_016912:c802167-801979 [Staphylococcus aureus subsp. aureus VC40]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26095 WP_001059690.1 NC_016912:c802456-802196 [Staphylococcus aureus subsp. aureus VC40]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26095 NC_016912:c802456-802196 [Staphylococcus aureus subsp. aureus VC40]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References