Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 746470..747263 Replicon chromosome
Accession NZ_CP107367
Organism Klebsiella pneumoniae strain CRKP_32

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OH524_RS03740 Protein ID WP_004150910.1
Coordinates 746778..747263 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag OH524_RS03735 Protein ID WP_272029500.1
Coordinates 746470..746781 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH524_RS03720 742242..743390 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OH524_RS03725 743401..744777 - 1377 WP_004217775.1 cystathionine beta-synthase -
OH524_RS03730 745505..746473 + 969 WP_013362812.1 IS5-like element IS903B family transposase -
OH524_RS03735 746470..746781 + 312 WP_272029500.1 DUF1778 domain-containing protein Antitoxin
OH524_RS03740 746778..747263 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OH524_RS03745 747967..748560 + 594 WP_004188553.1 hypothetical protein -
OH524_RS03750 748657..748873 + 217 Protein_737 transposase -
OH524_RS03755 749479..750351 + 873 WP_004188557.1 ParA family protein -
OH524_RS03760 750351..750734 + 384 WP_004150906.1 hypothetical protein -
OH524_RS03765 750727..752094 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 745550..748809 3259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(18-101)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T260942 WP_004150910.1 NZ_CP107367:746778-747263 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11580.14 Da        Isoelectric Point: 6.3878

>AT260942 WP_272029500.1 NZ_CP107367:746470-746781 [Klebsiella pneumoniae]
MKTQPATGETYPKSDLFNKANLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLD
QAPAPNAALRKTMQTPAPWEQEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure

References