Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2794167..2794792 Replicon chromosome
Accession NZ_CP107363
Organism Klebsiella pneumoniae strain CRKP_33

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH511_RS13820 Protein ID WP_002882817.1
Coordinates 2794409..2794792 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH511_RS13815 Protein ID WP_004150355.1
Coordinates 2794167..2794409 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH511_RS13790 2790158..2790757 + 600 WP_004151865.1 glucose-1-phosphatase -
OH511_RS13795 2790751..2791611 + 861 WP_002882807.1 virulence factor BrkB family protein -
OH511_RS13800 2791608..2792045 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH511_RS13805 2792090..2793031 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH511_RS13810 2793045..2793962 - 918 WP_002882812.1 alpha/beta hydrolase -
OH511_RS13815 2794167..2794409 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH511_RS13820 2794409..2794792 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH511_RS13825 2794966..2795895 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH511_RS13830 2795892..2796527 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH511_RS13835 2796524..2797426 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T260926 WP_002882817.1 NZ_CP107363:2794409-2794792 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT260926 WP_004150355.1 NZ_CP107363:2794167-2794409 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References