Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1838826..1839480 Replicon chromosome
Accession NZ_CP107363
Organism Klebsiella pneumoniae strain CRKP_33

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH511_RS09025 Protein ID WP_004144731.1
Coordinates 1838826..1839233 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH511_RS09030 Protein ID WP_002916312.1
Coordinates 1839214..1839480 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH511_RS09005 1834826..1836559 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
OH511_RS09010 1836565..1837278 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH511_RS09015 1837301..1838197 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH511_RS09020 1838298..1838819 + 522 WP_002916308.1 flavodoxin FldB -
OH511_RS09025 1838826..1839233 - 408 WP_004144731.1 protein YgfX Toxin
OH511_RS09030 1839214..1839480 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH511_RS09035 1839726..1840709 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH511_RS09040 1840860..1841519 - 660 WP_002916317.1 hemolysin III family protein -
OH511_RS09045 1841683..1841994 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH511_RS09050 1842044..1842772 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH511_RS09055 1842891..1844324 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T260923 WP_004144731.1 NZ_CP107363:c1839233-1838826 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260923 WP_002916312.1 NZ_CP107363:c1839480-1839214 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References