Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 91854..92497 Replicon plasmid unnamed1
Accession NZ_CP107360
Organism Klebsiella pneumoniae strain CRKP_34

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH518_RS27485 Protein ID WP_001044770.1
Coordinates 91854..92270 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH518_RS27490 Protein ID WP_001261282.1
Coordinates 92267..92497 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH518_RS27465 (87957) 87957..88229 - 273 Protein_110 transposase -
OH518_RS27475 (89211) 89211..90233 - 1023 WP_000361404.1 helicase UvrD -
OH518_RS27480 (90218) 90218..91780 - 1563 WP_004206609.1 AAA family ATPase -
OH518_RS27485 (91854) 91854..92270 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH518_RS27490 (92267) 92267..92497 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH518_RS27495 (92454) 92454..92915 + 462 WP_014343465.1 hypothetical protein -
OH518_RS27500 (93076) 93076..94020 + 945 WP_011977810.1 hypothetical protein -
OH518_RS27505 (94057) 94057..94449 + 393 WP_011977811.1 hypothetical protein -
OH518_RS27510 (94507) 94507..95028 + 522 WP_013214008.1 hypothetical protein -
OH518_RS27515 (95074) 95074..95277 + 204 WP_011977813.1 hypothetical protein -
OH518_RS27520 (95307) 95307..96311 + 1005 WP_011977814.1 hypothetical protein -
OH518_RS27525 (96495) 96495..97274 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..155508 155508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260916 WP_001044770.1 NZ_CP107360:c92270-91854 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260916 WP_001261282.1 NZ_CP107360:c92497-92267 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References