Detailed information of TA system TA026091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 930042..930736
• Replicon: chromosome
• Accession: NC_016901
• Organism: Shewanella baltica OS678

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A9L1Q5
• Locus tag: SBAL678_RS27430
• Protein ID: WP_012196688.1
• Coordinates: 930042..930419 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SBAL678_RS27435
• Protein ID: WP_012196689.1
• Coordinates: 930431..930736 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL678_RS27400	925435..927441	+	2007	WP_012196683.1	Clp protease ClpP	-
SBAL678_RS27405	927522..927845	+	324	WP_012196684.1	DUF2190 family protein	-
SBAL678_RS27410	927838..928182	+	345	WP_012196685.1	hypothetical protein	-
SBAL678_RS27415	928186..928743	+	558	WP_012196686.1	hypothetical protein	-
SBAL678_RS27420	928777..929202	+	426	WP_012088287.1	hypothetical protein	-
SBAL678_RS27425	929199..929918	+	720	WP_014357922.1	hypothetical protein	-
SBAL678_RS27430	930042..930419	+	378	WP_012196688.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL678_RS27435	930431..930736	+	306	WP_012196689.1	DNA-binding transcriptional regulator	Antitoxin
SBAL678_RS27440	930813..931397	-	585	WP_012196690.1	Rha family transcriptional regulator	-
SBAL678_RS46745	931482..931670	-	189	WP_080514246.1	ash family protein	-
SBAL678_RS27445	931713..932081	-	369	WP_012196691.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	891750..944799	53049

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (3-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-98)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13878.10 Da
• Isoelectric Point: 10.2058

>T26091 WP_012196688.1 NC_016901:930042-930419 [Shewanella baltica OS678]
VGRIFKTPDFVTWAKDEGVNDKALLDAVKEIEAGLIDANLGGNVIKKRVAREGQGKSGGFRTLLAFKSQDKSFFMFGFAK
NERENISVKEKAALKAMAKEFFAYDDKALIKAIKAKALYEIKQDV

Nucleotide

• Length: 378 bp

>T26091 NC_016901:930042-930419 [Shewanella baltica OS678]
GTGGGGCGAATATTCAAAACACCTGACTTTGTAACTTGGGCAAAAGACGAAGGTGTGAATGATAAAGCCTTGTTAGATGC
TGTAAAGGAAATTGAAGCCGGATTAATAGATGCAAATCTTGGTGGCAATGTTATTAAAAAACGTGTCGCGCGAGAAGGCC
AAGGTAAAAGTGGTGGATTTAGAACCCTTTTAGCCTTTAAATCGCAAGATAAGTCTTTCTTTATGTTTGGTTTTGCTAAA
AATGAAAGAGAGAATATTTCAGTTAAAGAAAAGGCAGCCTTGAAAGCTATGGCTAAAGAGTTTTTTGCTTACGATGATAA
AGCATTGATTAAAGCTATAAAAGCCAAAGCACTGTATGAGATTAAACAAGATGTATGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11151.12 Da
• Isoelectric Point: 10.3224

>AT26091 WP_012196689.1 NC_016901:930431-930736 [Shewanella baltica OS678]
MSRLLKSLHNTAKGLHDAGVMKTSTMREFDELCLPEIKVLTAAEIKRIRVANNVSQPVFAHCLNVSVSSVQKWEQGTRHP
DGPALTLLNLVKKQGMSLLMA

Nucleotide

• Length: 306 bp

>AT26091 NC_016901:930431-930736 [Shewanella baltica OS678]
ATGAGTCGTTTACTTAAGTCACTGCATAATACCGCCAAAGGCTTGCATGATGCGGGTGTCATGAAAACATCGACCATGCG
TGAATTTGACGAACTTTGCTTACCTGAAATCAAAGTACTAACAGCTGCGGAAATTAAGCGCATTAGAGTCGCGAATAATG
TCAGCCAGCCTGTATTTGCCCATTGCTTAAATGTTTCAGTATCCAGTGTGCAAAAGTGGGAACAAGGCACAAGGCATCCT
GACGGTCCTGCCTTGACGCTGCTAAATCTCGTTAAAAAACAAGGTATGTCTTTGCTGATGGCTTGA

Structures

Toxin

• AlphaFold DB: A9L1Q5