Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4183927..4184546 Replicon chromosome
Accession NZ_CP107359
Organism Klebsiella pneumoniae strain CRKP_34

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH518_RS20815 Protein ID WP_002892050.1
Coordinates 4184328..4184546 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH518_RS20810 Protein ID WP_002892066.1
Coordinates 4183927..4184301 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH518_RS20800 4179079..4180272 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH518_RS20805 4180295..4183441 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH518_RS20810 4183927..4184301 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH518_RS20815 4184328..4184546 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH518_RS20820 4184705..4185271 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH518_RS20825 4185243..4185383 - 141 WP_004147370.1 hypothetical protein -
OH518_RS20830 4185404..4185874 + 471 WP_002892026.1 YlaC family protein -
OH518_RS20835 4185849..4187300 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH518_RS20840 4187401..4188099 + 699 WP_002892021.1 GNAT family protein -
OH518_RS20845 4188096..4188236 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH518_RS20850 4188236..4188499 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260904 WP_002892050.1 NZ_CP107359:4184328-4184546 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT260904 WP_002892066.1 NZ_CP107359:4183927-4184301 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References