Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 274518..275155 Replicon plasmid unnamed1
Accession NZ_CP107353
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OH515_RS26570 Protein ID WP_087638532.1
Coordinates 274745..275155 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag OH515_RS26565 Protein ID WP_044265857.1
Coordinates 274518..274748 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS26550 270230..270838 + 609 WP_044265848.1 hypothetical protein -
OH515_RS26555 270831..271712 + 882 WP_044265851.1 hypothetical protein -
OH515_RS26560 271992..274130 - 2139 WP_044265854.1 AAA family ATPase -
OH515_RS26565 274518..274748 + 231 WP_044265857.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH515_RS26570 274745..275155 + 411 WP_087638532.1 PIN domain-containing protein Toxin
OH515_RS26575 275314..276294 + 981 WP_044265863.1 hypothetical protein -
OH515_RS26580 276542..277243 + 702 WP_044265986.1 aspartate/glutamate racemase family protein -
OH515_RS26585 277250..277375 - 126 Protein_301 IS5/IS1182 family transposase -
OH515_RS26590 277751..278212 - 462 WP_044265866.1 Lrp/AsnC family transcriptional regulator -
OH515_RS26595 278421..279515 + 1095 WP_272049723.1 aromatic amino acid transport family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..299789 299789
- flank IS/Tn - - 279760..280263 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14426.37 Da        Isoelectric Point: 4.4964

>T260892 WP_087638532.1 NZ_CP107353:274745-275155 [Klebsiella pneumoniae]
VNRTYMLDTRFCAFILREQPEAVLGWLEQAVLRGHRIVISAITWAELSQAAREDSPATQALADAFCASLDVVLPWDRAAV
DATTEIKAALAATGTPLGPNDTAIAGHAIAAGAVLVTRNGGEFERVPGLTLQDWAG

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8575.81 Da        Isoelectric Point: 5.0957

>AT260892 WP_044265857.1 NZ_CP107353:274518-274748 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDCIILRPVRPAWNSFALMGKAGPEFMAEREVVISDNGRGEQ

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References