Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 255323..255966 Replicon plasmid unnamed1
Accession NZ_CP107353
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag OH515_RS26480 Protein ID WP_032720618.1
Coordinates 255550..255966 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag OH515_RS26475 Protein ID WP_032720617.1
Coordinates 255323..255553 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS26455 250894..251826 + 933 WP_032720614.1 S-4TM family putative pore-forming effector -
OH515_RS26460 252136..252720 + 585 WP_032720615.1 hypothetical protein -
OH515_RS26465 252785..254026 + 1242 WP_032720616.1 RES family NAD+ phosphorylase -
OH515_RS26470 254116..254982 - 867 WP_050548602.1 hypothetical protein -
OH515_RS26475 255323..255553 + 231 WP_032720617.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH515_RS26480 255550..255966 + 417 WP_032720618.1 type II toxin-antitoxin system VapC family toxin Toxin
OH515_RS26485 256040..257602 + 1563 WP_032720619.1 AAA family ATPase -
OH515_RS26490 257587..258609 + 1023 WP_159196574.1 DNA helicase UvrD -
OH515_RS26495 258997..259194 - 198 Protein_283 transposase -
OH515_RS26500 259558..260070 + 513 WP_032720621.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..299789 299789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15179.60 Da        Isoelectric Point: 7.2453

>T260891 WP_032720618.1 NZ_CP107353:255550-255966 [Klebsiella pneumoniae]
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 4.3775

>AT260891 WP_032720617.1 NZ_CP107353:255323-255553 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References