Detailed information of TA system TA026089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 820379..821920
• Replicon: chromosome
• Accession: NC_016901
• Organism: Shewanella baltica OS678

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A9L0C7
• Locus tag: SBAL678_RS26830
• Protein ID: WP_006086107.1
• Coordinates: 820619..821920 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL678_RS26825
• Protein ID: WP_006086108.1
• Coordinates: 820379..820615 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL678_RS26810	817808..818983	+	1176	WP_006086111.1	HEAT repeat domain-containing protein	-
SBAL678_RS26815	819035..819220	-	186	WP_006086110.1	hypothetical protein	-
SBAL678_RS26820	819296..819535	-	240	WP_006086109.1	esterase	-
SBAL678_RS26825	820379..820615	+	237	WP_006086108.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
SBAL678_RS26830	820619..821920	+	1302	WP_006086107.1	HipA domain-containing protein	Toxin
SBAL678_RS26835	822436..822705	+	270	WP_006086106.1	hypothetical protein	-
SBAL678_RS26840	823235..823657	+	423	WP_006086105.1	hypothetical protein	-
SBAL678_RS26845	823770..825170	-	1401	WP_006086104.1	GGDEF domain-containing protein	-
SBAL678_RS26850	825544..825930	+	387	WP_006086103.1	carboxymuconolactone decarboxylase family protein	-
SBAL678_RS26855	826073..826324	-	252	WP_006083102.1	DUF2999 domain-containing protein	-
SBAL678_RS47320	826342..826566	+	225	WP_148228712.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (146-360)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48702.88 Da
• Isoelectric Point: 5.1856

>T26089 WP_006086107.1 NC_016901:820619-821920 [Shewanella baltica OS678]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALD
ENETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Nucleotide

• Length: 1302 bp

>T26089 NC_016901:820619-821920 [Shewanella baltica OS678]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAAGATTTTGAACAACAGCTTGCTATGGCAATCGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGATTTACCACGGAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGGCCCTCGAT
GAGAATGAAACATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8574.91 Da
• Isoelectric Point: 7.9728

>AT26089 WP_006086108.1 NC_016901:820379-820615 [Shewanella baltica OS678]
MASRLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIEIVSAQTSDTETNGWY

Nucleotide

• Length: 237 bp

>AT26089 NC_016901:820379-820615 [Shewanella baltica OS678]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Structures

Toxin

• AlphaFold DB: A9L0C7