Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 174054..174805 Replicon plasmid unnamed1
Accession NZ_CP107353
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OH515_RS26040 Protein ID WP_048333033.1
Coordinates 174323..174805 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OH515_RS26035 Protein ID WP_004902250.1
Coordinates 174054..174332 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS26015 171325..171807 + 483 WP_172694439.1 hypothetical protein -
OH515_RS26020 172051..172365 - 315 WP_023288299.1 hypothetical protein -
OH515_RS26025 173271..173612 + 342 WP_032437747.1 hypothetical protein -
OH515_RS26030 173720..173932 + 213 WP_016946198.1 hypothetical protein -
OH515_RS26035 174054..174332 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OH515_RS26040 174323..174805 + 483 WP_048333033.1 GNAT family N-acetyltransferase Toxin
OH515_RS26045 175840..176379 + 540 WP_004902239.1 hypothetical protein -
OH515_RS26050 176484..176876 + 393 WP_032442757.1 hypothetical protein -
OH515_RS26055 176977..177732 + 756 WP_004902235.1 DUF2971 domain-containing protein -
OH515_RS26060 177759..178406 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..299789 299789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17708.53 Da        Isoelectric Point: 8.9130

>T260889 WP_048333033.1 NZ_CP107353:174323-174805 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT260889 WP_004902250.1 NZ_CP107353:174054-174332 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References