260887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 36296..36818 Replicon plasmid unnamed1
Accession NZ_CP107353
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag OH515_RS25260 Protein ID WP_044265921.1
Coordinates 36296..36580 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag OH515_RS25265 Protein ID WP_004187025.1
Coordinates 36570..36818 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS25245 33228..33746 + 519 WP_227627021.1 DinB family protein -
OH515_RS25250 33868..34833 - 966 WP_044265916.1 hypothetical protein -
OH515_RS25255 35006..36280 + 1275 WP_044265918.1 ISNCY family transposase -
OH515_RS25260 36296..36580 - 285 WP_044265921.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH515_RS25265 36570..36818 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
OH515_RS25270 37227..37694 - 468 WP_044265924.1 GNAT family N-acetyltransferase -
OH515_RS25275 38080..38637 + 558 WP_044265927.1 OsmC family protein -
OH515_RS25280 38824..39393 + 570 WP_044265930.1 TetR/AcrR family transcriptional regulator -
OH515_RS25285 39411..39749 + 339 WP_044265932.1 carboxymuconolactone decarboxylase family protein -
OH515_RS25290 40158..40526 + 369 Protein_42 Arm DNA-binding domain-containing protein -
OH515_RS25295 40529..40741 + 213 Protein_43 DUF3363 domain-containing protein -
OH515_RS25300 40770..41591 - 822 WP_044265935.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..299789 299789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11012.73 Da        Isoelectric Point: 10.5388

>T260887 WP_044265921.1 NZ_CP107353:c36580-36296 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVHFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT260887 WP_004187025.1 NZ_CP107353:c36818-36570 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References