Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4306377..4306967 Replicon chromosome
Accession NZ_CP107352
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OH515_RS20685 Protein ID WP_032421545.1
Coordinates 4306635..4306967 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OH515_RS20680 Protein ID WP_032421546.1
Coordinates 4306377..4306634 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS20665 (4303706) 4303706..4304968 - 1263 WP_198921206.1 hypothetical protein -
OH515_RS20670 (4305353) 4305353..4305826 + 474 WP_050597676.1 hypothetical protein -
OH515_RS20675 (4305823) 4305823..4306029 + 207 WP_080217966.1 helix-turn-helix transcriptional regulator -
OH515_RS20680 (4306377) 4306377..4306634 + 258 WP_032421546.1 antitoxin Antitoxin
OH515_RS20685 (4306635) 4306635..4306967 + 333 WP_032421545.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OH515_RS20695 (4307289) 4307289..4308725 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OH515_RS20705 (4309091) 4309091..4310545 - 1455 WP_004148975.1 AMP nucleosidase -
OH515_RS20710 (4310675) 4310675..4310920 - 246 WP_064162645.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4296616..4306967 10351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11917.79 Da        Isoelectric Point: 10.0968

>T260882 WP_032421545.1 NZ_CP107352:4306635-4306967 [Klebsiella pneumoniae]
MDRGEIWLVSLDPTSGHEQSGKRPVLIVSKASFNKLTQLPVIVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9175.62 Da        Isoelectric Point: 4.7468

>AT260882 WP_032421546.1 NZ_CP107352:4306377-4306634 [Klebsiella pneumoniae]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDNGCLVIEPQKRPHYSLEELLAQCDPHAEISEGGREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References