Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3383223..3383880 Replicon chromosome
Accession NZ_CP107352
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OH515_RS16365 Protein ID WP_002916310.1
Coordinates 3383470..3383880 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH515_RS16360 Protein ID WP_002916312.1
Coordinates 3383223..3383489 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS16335 (3378379) 3378379..3379812 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OH515_RS16340 (3379931) 3379931..3380659 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH515_RS16345 (3380709) 3380709..3381020 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
OH515_RS16350 (3381184) 3381184..3381843 + 660 WP_002916317.1 hemolysin III family protein -
OH515_RS16355 (3381994) 3381994..3382977 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH515_RS16360 (3383223) 3383223..3383489 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH515_RS16365 (3383470) 3383470..3383880 + 411 WP_002916310.1 protein YgfX Toxin
OH515_RS16370 (3383887) 3383887..3384408 - 522 WP_002916308.1 flavodoxin FldB -
OH515_RS16375 (3384509) 3384509..3385405 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH515_RS16380 (3385428) 3385428..3386141 + 714 WP_135696293.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH515_RS16385 (3386147) 3386147..3387880 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T260881 WP_002916310.1 NZ_CP107352:3383470-3383880 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260881 WP_002916312.1 NZ_CP107352:3383223-3383489 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References