Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 31664..33252 Replicon chromosome
Accession NZ_CP107352
Organism Klebsiella pneumoniae strain CRKP_35

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OH515_RS00155 Protein ID WP_135695488.1
Coordinates 31664..32986 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OH515_RS00160 Protein ID WP_004176198.1
Coordinates 32986..33252 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH515_RS00140 (26732) 26732..29233 + 2502 WP_135695490.1 fimbria/pilus outer membrane usher protein -
OH515_RS00145 (29221) 29221..30225 + 1005 WP_004176196.1 fimbrial protein -
OH515_RS00150 (30367) 30367..31722 + 1356 WP_227648220.1 glycoside hydrolase family 10 protein -
OH515_RS00155 (31664) 31664..32986 - 1323 WP_135695488.1 type II toxin-antitoxin system HipA family toxin Toxin
OH515_RS00160 (32986) 32986..33252 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OH515_RS00165 (33518) 33518..33844 - 327 WP_004215084.1 hydroxyisourate hydrolase -
OH515_RS00170 (33841) 33841..34341 - 501 WP_135695486.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OH515_RS00175 (34319) 34319..35698 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OH515_RS00180 (36044) 36044..37198 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OH515_RS00185 (37179) 37179..38102 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49083.36 Da        Isoelectric Point: 7.5357

>T260873 WP_135695488.1 NZ_CP107352:c32986-31664 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSVYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT260873 WP_004176198.1 NZ_CP107352:c33252-32986 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References