260843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 57982..58625 Replicon plasmid unnamed1
Accession NZ_CP107342
Organism Klebsiella pneumoniae strain CRKP_37

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH503_RS28230 Protein ID WP_001044770.1
Coordinates 57982..58398 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH503_RS28235 Protein ID WP_001261282.1
Coordinates 58395..58625 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH503_RS28210 (54085) 54085..54357 - 273 Protein_81 transposase -
OH503_RS28220 (55339) 55339..56361 - 1023 WP_000361404.1 helicase UvrD -
OH503_RS28225 (56346) 56346..57908 - 1563 WP_004206609.1 AAA family ATPase -
OH503_RS28230 (57982) 57982..58398 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH503_RS28235 (58395) 58395..58625 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH503_RS28240 (58582) 58582..59043 + 462 WP_014343465.1 hypothetical protein -
OH503_RS28245 (59204) 59204..60148 + 945 WP_011977810.1 hypothetical protein -
OH503_RS28250 (60185) 60185..60577 + 393 WP_011977811.1 hypothetical protein -
OH503_RS28255 (60635) 60635..61156 + 522 WP_013214008.1 hypothetical protein -
OH503_RS28260 (61202) 61202..61405 + 204 WP_011977813.1 hypothetical protein -
OH503_RS28265 (61435) 61435..62439 + 1005 WP_011977814.1 hypothetical protein -
OH503_RS28270 (62623) 62623..63402 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 - 1..88043 88043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260843 WP_001044770.1 NZ_CP107342:c58398-57982 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260843 WP_001261282.1 NZ_CP107342:c58625-58395 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References