Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2461..2986 Replicon plasmid pSTUK-100
Accession NC_016864
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag STMUK_RS23250 Protein ID WP_001159863.1
Coordinates 2681..2986 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag STMUK_RS23245 Protein ID WP_000813641.1
Coordinates 2461..2679 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STMUK_RS25775 484..780 - 297 WP_001687482.1 hypothetical protein -
STMUK_RS23240 1264..1785 - 522 WP_010999942.1 hypothetical protein -
STMUK_RS23245 2461..2679 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
STMUK_RS23250 2681..2986 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
STMUK_RS23255 2988..3278 + 291 WP_001266176.1 hypothetical protein -
STMUK_RS23260 3275..3796 + 522 WP_000198608.1 hypothetical protein -
STMUK_RS23265 3831..4613 + 783 WP_000082169.1 site-specific integrase -
STMUK_RS23270 4622..5335 + 714 Protein_7 EAL domain-containing protein -
STMUK_RS23275 5339..5848 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
STMUK_RS23280 5842..6327 + 486 WP_000905606.1 membrane protein -
STMUK_RS23285 6580..6936 + 357 Protein_10 LysM peptidoglycan-binding domain-containing protein -
STMUK_RS26200 6934..7029 + 96 Protein_11 adenylate cyclase -
STMUK_RS23290 7096..7446 - 351 WP_014344526.1 helix-turn-helix domain-containing protein -
STMUK_RS25315 7503..7927 + 425 Protein_13 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93277 93277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-95)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T26084 WP_001159863.1 NC_016864:2681-2986 [Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T26084 NC_016864:2681-2986 [Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT26084 WP_000813641.1 NC_016864:2461-2679 [Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT26084 NC_016864:2461-2679 [Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References