Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3671709..3672363 Replicon chromosome
Accession NZ_CP107341
Organism Klebsiella pneumoniae strain CRKP_37

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH503_RS18260 Protein ID WP_004144731.1
Coordinates 3671956..3672363 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH503_RS18255 Protein ID WP_002916312.1
Coordinates 3671709..3671975 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH503_RS18230 (3666865) 3666865..3668298 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OH503_RS18235 (3668417) 3668417..3669145 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH503_RS18240 (3669195) 3669195..3669506 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH503_RS18245 (3669670) 3669670..3670329 + 660 WP_002916317.1 hemolysin III family protein -
OH503_RS18250 (3670480) 3670480..3671463 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH503_RS18255 (3671709) 3671709..3671975 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH503_RS18260 (3671956) 3671956..3672363 + 408 WP_004144731.1 protein YgfX Toxin
OH503_RS18265 (3672370) 3672370..3672891 - 522 WP_002916308.1 flavodoxin FldB -
OH503_RS18270 (3672992) 3672992..3673888 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH503_RS18275 (3673911) 3673911..3674624 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH503_RS18280 (3674630) 3674630..3676363 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T260836 WP_004144731.1 NZ_CP107341:3671956-3672363 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260836 WP_002916312.1 NZ_CP107341:3671709-3671975 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References