Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2716864..2717489 | Replicon | chromosome |
Accession | NZ_CP107341 | ||
Organism | Klebsiella pneumoniae strain CRKP_37 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | OH503_RS13480 | Protein ID | WP_002882817.1 |
Coordinates | 2716864..2717247 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | OH503_RS13485 | Protein ID | WP_004150355.1 |
Coordinates | 2717247..2717489 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OH503_RS13465 (2714230) | 2714230..2715132 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
OH503_RS13470 (2715129) | 2715129..2715764 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
OH503_RS13475 (2715761) | 2715761..2716690 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
OH503_RS13480 (2716864) | 2716864..2717247 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
OH503_RS13485 (2717247) | 2717247..2717489 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
OH503_RS13490 (2717694) | 2717694..2718611 | + | 918 | WP_002882812.1 | alpha/beta hydrolase | - |
OH503_RS13495 (2718625) | 2718625..2719566 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
OH503_RS13500 (2719611) | 2719611..2720048 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
OH503_RS13505 (2720045) | 2720045..2720905 | - | 861 | WP_002882807.1 | virulence factor BrkB family protein | - |
OH503_RS13510 (2720899) | 2720899..2721498 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T260833 WP_002882817.1 NZ_CP107341:c2717247-2716864 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |