Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2392779..2394460 Replicon chromosome
Accession NZ_CP107341
Organism Klebsiella pneumoniae strain CRKP_37

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OH503_RS11975 Protein ID WP_002885155.1
Coordinates 2392779..2393696 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag OH503_RS11980 Protein ID WP_004151732.1
Coordinates 2393702..2394460 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH503_RS11955 (2388085) 2388085..2389605 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OH503_RS11960 (2389602) 2389602..2390600 + 999 WP_002885172.1 ribose ABC transporter permease -
OH503_RS11965 (2390631) 2390631..2391572 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OH503_RS11970 (2391647) 2391647..2392654 + 1008 WP_004151731.1 carbohydrate kinase family protein -
OH503_RS11975 (2392779) 2392779..2393696 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OH503_RS11980 (2393702) 2393702..2394460 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OH503_RS11985 (2394546) 2394546..2395274 - 729 WP_002885152.1 response regulator transcription factor -
OH503_RS11990 (2395547) 2395547..2397694 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
OH503_RS11995 (2397924) 2397924..2398610 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T260832 WP_002885155.1 NZ_CP107341:c2393696-2392779 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT260832 WP_004151732.1 NZ_CP107341:c2394460-2393702 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References