260831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2153185..2153701 Replicon chromosome
Accession NZ_CP107341
Organism Klebsiella pneumoniae strain CRKP_37

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OH503_RS10645 Protein ID WP_002886902.1
Coordinates 2153185..2153469 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OH503_RS10650 Protein ID WP_002886901.1
Coordinates 2153459..2153701 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH503_RS10620 (2148669) 2148669..2148977 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
OH503_RS10625 (2149062) 2149062..2149235 + 174 WP_002886906.1 hypothetical protein -
OH503_RS10630 (2149238) 2149238..2149981 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OH503_RS10635 (2150338) 2150338..2152476 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OH503_RS10640 (2152717) 2152717..2153181 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OH503_RS10645 (2153185) 2153185..2153469 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH503_RS10650 (2153459) 2153459..2153701 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OH503_RS10655 (2153779) 2153779..2155689 - 1911 WP_004152270.1 PRD domain-containing protein -
OH503_RS10660 (2155712) 2155712..2156866 - 1155 WP_002886900.1 lactonase family protein -
OH503_RS10665 (2156932) 2156932..2157672 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T260831 WP_002886902.1 NZ_CP107341:c2153469-2153185 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT260831 WP_002886901.1 NZ_CP107341:c2153701-2153459 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References