Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4184949..4185568 Replicon chromosome
Accession NZ_CP107334
Organism Klebsiella pneumoniae strain CRKP_38

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH514_RS20885 Protein ID WP_002892050.1
Coordinates 4185350..4185568 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH514_RS20880 Protein ID WP_002892066.1
Coordinates 4184949..4185323 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH514_RS20870 4180101..4181294 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH514_RS20875 4181317..4184463 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH514_RS20880 4184949..4185323 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH514_RS20885 4185350..4185568 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH514_RS20890 4185727..4186293 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH514_RS20895 4186265..4186405 - 141 WP_004147370.1 hypothetical protein -
OH514_RS20900 4186426..4186896 + 471 WP_002892026.1 YlaC family protein -
OH514_RS20905 4186871..4188322 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH514_RS20910 4188423..4189121 + 699 WP_002892021.1 GNAT family protein -
OH514_RS20915 4189118..4189258 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH514_RS20920 4189258..4189521 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260811 WP_002892050.1 NZ_CP107334:4185350-4185568 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT260811 WP_002892066.1 NZ_CP107334:4184949-4185323 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References