260765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 77708..78351 Replicon plasmid unnamed1
Accession NZ_CP107321
Organism Klebsiella pneumoniae strain CRKP_40

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH527_RS27370 Protein ID WP_001044770.1
Coordinates 77708..78124 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH527_RS27375 Protein ID WP_001261282.1
Coordinates 78121..78351 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH527_RS27350 73811..74083 - 273 Protein_87 transposase -
OH527_RS27360 75065..76087 - 1023 WP_000361404.1 helicase UvrD -
OH527_RS27365 76072..77634 - 1563 WP_004206609.1 AAA family ATPase -
OH527_RS27370 77708..78124 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH527_RS27375 78121..78351 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH527_RS27380 78308..78724 + 417 WP_164481821.1 hypothetical protein -
OH527_RS27385 79269..80090 + 822 WP_004213562.1 hypothetical protein -
OH527_RS27390 80087..80866 + 780 WP_004213560.1 site-specific integrase -
OH527_RS27395 81011..81940 - 930 WP_004213558.1 Rpn family recombination-promoting nuclease/putative transposase -
OH527_RS27400 82244..82411 + 168 Protein_97 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / rmpA / iroN / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..193826 193826
- inside IScluster/Tn - - 54659..74615 19956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260765 WP_001044770.1 NZ_CP107321:c78124-77708 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260765 WP_001261282.1 NZ_CP107321:c78351-78121 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References