Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2925..3835 Replicon plasmid unnamed2
Accession NZ_CP107314
Organism Klebsiella pneumoniae strain CRKP_41

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag OH506_RS28325 Protein ID WP_004026354.1
Coordinates 2925..3395 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag OH506_RS28330 Protein ID WP_004026357.1
Coordinates 3392..3835 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH506_RS28315 43..693 + 651 WP_068893702.1 DUF1173 family protein -
OH506_RS28325 2925..3395 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
OH506_RS28330 3392..3835 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
OH506_RS28335 3936..4439 - 504 Protein_4 DUF4113 domain-containing protein -
OH506_RS28340 4645..5625 - 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
OH506_RS28345 5691..6998 + 1308 Protein_6 FepA family TonB-dependent siderophore receptor -
OH506_RS28350 7060..7281 + 222 WP_004213615.1 hypothetical protein -
OH506_RS28355 7424..8326 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
OH506_RS28360 8399..8800 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..126785 126785
- inside IScluster/Tn - - 2079..5625 3546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T260744 WP_004026354.1 NZ_CP107314:c3395-2925 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT260744 WP_004026357.1 NZ_CP107314:c3835-3392 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References