260721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2084..2558 Replicon plasmid unnamed3
Accession NZ_CP107311
Organism Klebsiella pneumoniae strain CRKP_42

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag OH538_RS27995 Protein ID WP_004197762.1
Coordinates 2292..2558 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag OH538_RS27990 Protein ID WP_000879771.1
Coordinates 2084..2308 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH538_RS27975 220..654 + 435 Protein_1 relaxase/mobilization nuclease domain-containing protein -
OH538_RS27980 689..1198 + 510 WP_032433972.1 MbeB family mobilization protein -
OH538_RS27985 1205..1417 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
OH538_RS27990 2084..2308 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
OH538_RS27995 2292..2558 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH538_RS28000 2628..2978 - 351 WP_004197756.1 hypothetical protein -
OH538_RS28005 3044..3589 - 546 WP_023317533.1 hypothetical protein -
OH538_RS28010 3615..3977 - 363 WP_232196750.1 hypothetical protein -
OH538_RS28015 5098..5274 + 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5597 5597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T260721 WP_004197762.1 NZ_CP107311:2292-2558 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT260721 WP_000879771.1 NZ_CP107311:2084-2308 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References