Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 65386..66029 Replicon plasmid unnamed1
Accession NZ_CP107304
Organism Klebsiella pneumoniae strain CRKP_43

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH504_RS27385 Protein ID WP_001044770.1
Coordinates 65386..65802 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH504_RS27390 Protein ID WP_001261282.1
Coordinates 65799..66029 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH504_RS27365 (61489) 61489..61761 - 273 Protein_84 transposase -
OH504_RS27375 (62743) 62743..63765 - 1023 WP_000361404.1 helicase UvrD -
OH504_RS27380 (63750) 63750..65312 - 1563 WP_004206609.1 AAA family ATPase -
OH504_RS27385 (65386) 65386..65802 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH504_RS27390 (65799) 65799..66029 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH504_RS27395 (65986) 65986..66447 + 462 WP_014343465.1 hypothetical protein -
OH504_RS27400 (66608) 66608..67552 + 945 WP_011977810.1 hypothetical protein -
OH504_RS27405 (67589) 67589..67981 + 393 WP_011977811.1 hypothetical protein -
OH504_RS27410 (68039) 68039..68560 + 522 WP_013214008.1 hypothetical protein -
OH504_RS27415 (68606) 68606..68809 + 204 WP_011977813.1 hypothetical protein -
OH504_RS27420 (68839) 68839..69843 + 1005 WP_011977814.1 hypothetical protein -
OH504_RS27425 (70027) 70027..70806 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..103669 103669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260698 WP_001044770.1 NZ_CP107304:c65802-65386 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260698 WP_001261282.1 NZ_CP107304:c66029-65799 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References