Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5438453..5440041 Replicon chromosome
Accession NZ_CP107303
Organism Klebsiella pneumoniae strain CRKP_43

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OH504_RS26845 Protein ID WP_004199851.1
Coordinates 5438719..5440041 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OH504_RS26840 Protein ID WP_002904790.1
Coordinates 5438453..5438719 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH504_RS26815 5433603..5434526 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
OH504_RS26820 5434507..5435661 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OH504_RS26825 5436007..5437386 + 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
OH504_RS26830 5437364..5437864 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OH504_RS26835 5437861..5438187 + 327 WP_002904788.1 hydroxyisourate hydrolase -
OH504_RS26840 5438453..5438719 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OH504_RS26845 5438719..5440041 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OH504_RS26850 5440058..5441350 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OH504_RS26855 5441483..5442487 - 1005 WP_004199852.1 fimbrial protein -
OH504_RS26860 5442475..5444976 - 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T260693 WP_004199851.1 NZ_CP107303:5438719-5440041 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT260693 WP_002904790.1 NZ_CP107303:5438453-5438719 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References