Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1851566..1852220 Replicon chromosome
Accession NZ_CP107303
Organism Klebsiella pneumoniae strain CRKP_43

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag OH504_RS09120 Protein ID WP_004144731.1
Coordinates 1851566..1851973 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OH504_RS09125 Protein ID WP_002916312.1
Coordinates 1851954..1852220 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH504_RS09100 1847566..1849299 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
OH504_RS09105 1849305..1850018 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OH504_RS09110 1850041..1850937 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OH504_RS09115 1851038..1851559 + 522 WP_002916308.1 flavodoxin FldB -
OH504_RS09120 1851566..1851973 - 408 WP_004144731.1 protein YgfX Toxin
OH504_RS09125 1851954..1852220 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OH504_RS09130 1852466..1853449 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OH504_RS09135 1853600..1854259 - 660 WP_002916317.1 hemolysin III family protein -
OH504_RS09140 1854423..1854734 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OH504_RS09145 1854784..1855512 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OH504_RS09150 1855631..1857064 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T260685 WP_004144731.1 NZ_CP107303:c1851973-1851566 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260685 WP_002916312.1 NZ_CP107303:c1852220-1851954 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References