260675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 61032..61675 Replicon plasmid unnamed2
Accession NZ_CP107299
Organism Klebsiella pneumoniae strain CRKP_44

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag OH517_RS29055 Protein ID WP_001044770.1
Coordinates 61032..61448 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag OH517_RS29060 Protein ID WP_001261282.1
Coordinates 61445..61675 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH517_RS29035 (57135) 57135..57407 - 273 Protein_76 transposase -
OH517_RS29045 (58389) 58389..59411 - 1023 WP_000361404.1 helicase UvrD -
OH517_RS29050 (59396) 59396..60958 - 1563 WP_004206609.1 AAA family ATPase -
OH517_RS29055 (61032) 61032..61448 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
OH517_RS29060 (61445) 61445..61675 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OH517_RS29065 (61632) 61632..62093 + 462 WP_014343465.1 hypothetical protein -
OH517_RS29070 (62254) 62254..63198 + 945 WP_011977810.1 hypothetical protein -
OH517_RS29075 (63235) 63235..63627 + 393 WP_011977811.1 hypothetical protein -
OH517_RS29080 (63685) 63685..64206 + 522 WP_013214008.1 hypothetical protein -
OH517_RS29085 (64252) 64252..64455 + 204 WP_011977813.1 hypothetical protein -
OH517_RS29090 (64485) 64485..65489 + 1005 WP_011977814.1 hypothetical protein -
OH517_RS29095 (65673) 65673..66452 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 / blaCTX-M-65 / tet(A) / blaLAP-2 / qnrS1 / dfrA14 / sul2 / fosA3 - 1..215446 215446


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T260675 WP_001044770.1 NZ_CP107299:c61448-61032 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT260675 WP_001261282.1 NZ_CP107299:c61675-61445 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References