Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 168822..169732 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP107298 | ||
| Organism | Klebsiella pneumoniae strain CRKP_44 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | OH517_RS28370 | Protein ID | WP_004026354.1 |
| Coordinates | 169262..169732 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | OH517_RS28365 | Protein ID | WP_004026357.1 |
| Coordinates | 168822..169265 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OH517_RS28335 | 163857..164258 | + | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
| OH517_RS28340 | 164331..165233 | + | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| OH517_RS28345 | 165376..165597 | - | 222 | WP_004213615.1 | hypothetical protein | - |
| OH517_RS28350 | 165659..166966 | - | 1308 | Protein_177 | FepA family TonB-dependent siderophore receptor | - |
| OH517_RS28355 | 167032..168012 | + | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| OH517_RS28360 | 168218..168721 | + | 504 | Protein_179 | DUF4113 domain-containing protein | - |
| OH517_RS28365 | 168822..169265 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| OH517_RS28370 | 169262..169732 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| OH517_RS28375 | 169881..170578 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| OH517_RS28380 | 171964..172614 | - | 651 | WP_068893702.1 | DUF1173 family protein | - |
| OH517_RS28385 | 172647..172913 | - | 267 | WP_223175074.1 | DUF1173 family protein | - |
| OH517_RS28390 | 173091..173585 | + | 495 | WP_004212794.1 | thermonuclease family protein | - |
| OH517_RS28395 | 173922..174320 | + | 399 | WP_004212796.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN | 1..217869 | 217869 | |
| - | inside | IScluster/Tn | - | - | 167032..175771 | 8739 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T260670 WP_004026354.1 NZ_CP107298:169262-169732 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT260670 WP_004026357.1 NZ_CP107298:168822-169265 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |