260668

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5448411..5449030 Replicon chromosome
Accession NZ_CP107297
Organism Klebsiella pneumoniae strain CRKP_44

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH517_RS27110 Protein ID WP_002892050.1
Coordinates 5448411..5448629 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH517_RS27115 Protein ID WP_002892066.1
Coordinates 5448656..5449030 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH517_RS27075 5444458..5444721 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
OH517_RS27080 5444721..5444861 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH517_RS27085 5444858..5445556 - 699 WP_002892021.1 GNAT family protein -
OH517_RS27090 5445657..5447108 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH517_RS27095 5447083..5447553 - 471 WP_002892026.1 YlaC family protein -
OH517_RS27100 5447574..5447714 + 141 WP_004147370.1 hypothetical protein -
OH517_RS27105 5447686..5448252 - 567 WP_002892030.1 maltose O-acetyltransferase -
OH517_RS27110 5448411..5448629 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OH517_RS27115 5448656..5449030 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH517_RS27120 5449516..5452662 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH517_RS27125 5452685..5453878 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260668 WP_002892050.1 NZ_CP107297:c5448629-5448411 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT260668 WP_002892066.1 NZ_CP107297:c5449030-5448656 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References