260664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4252187..4252812 Replicon chromosome
Accession NZ_CP107297
Organism Klebsiella pneumoniae strain CRKP_44

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH517_RS21370 Protein ID WP_002882817.1
Coordinates 4252429..4252812 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH517_RS21365 Protein ID WP_004150355.1
Coordinates 4252187..4252429 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH517_RS21340 4248178..4248777 + 600 WP_004151865.1 glucose-1-phosphatase -
OH517_RS21345 4248771..4249631 + 861 WP_002882807.1 virulence factor BrkB family protein -
OH517_RS21350 4249628..4250065 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH517_RS21355 4250110..4251051 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH517_RS21360 4251065..4251982 - 918 WP_002882812.1 alpha/beta hydrolase -
OH517_RS21365 4252187..4252429 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH517_RS21370 4252429..4252812 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH517_RS21375 4252986..4253915 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH517_RS21380 4253912..4254547 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH517_RS21385 4254544..4255446 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T260664 WP_002882817.1 NZ_CP107297:4252429-4252812 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT260664 WP_004150355.1 NZ_CP107297:4252187-4252429 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References