Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/-
Location 4798482..4799058 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag STM14_RS23730 Protein ID WP_001131963.1
Coordinates 4798482..4798769 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag STM14_RS23735 Protein ID WP_000063142.1
Coordinates 4798756..4799058 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS23720 (STM14_5438) 4793592..4797101 - 3510 WP_001043484.1 type I restriction-modification system endonuclease -
STM14_RS23725 (STM14_5439) 4797299..4798213 + 915 WP_000290512.1 restriction endonuclease -
STM14_RS23730 (STM14_5441) 4798482..4798769 + 288 WP_001131963.1 BrnT family toxin Toxin
STM14_RS23735 (STM14_5442) 4798756..4799058 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
STM14_RS23740 (STM14_5443) 4799133..4800089 - 957 WP_000187839.1 GTPase -
STM14_RS23745 (STM14_5444) 4800100..4800303 - 204 WP_000460616.1 YbdD/YjiX family protein -
STM14_RS23750 (STM14_5445) 4800398..4802548 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T26065 WP_001131963.1 NC_016856:4798482-4798769 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T26065 NC_016856:4798482-4798769 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT26065 WP_000063142.1 NC_016856:4798756-4799058 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT26065 NC_016856:4798756-4799058 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References