Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 4704281..4704797 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag STM14_RS23325 Protein ID WP_000220578.1
Coordinates 4704513..4704797 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag STM14_RS23320 Protein ID WP_000212724.1
Coordinates 4704281..4704523 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS23300 (STM14_5336) 4699301..4700434 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
STM14_RS23305 (STM14_5337) 4700418..4701536 + 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
STM14_RS23310 (STM14_5338) 4701533..4702273 + 741 WP_000779263.1 KDGP aldolase family protein -
STM14_RS23315 (STM14_5339) 4702290..4704203 + 1914 WP_001212137.1 BglG family transcription antiterminator -
STM14_RS23320 (STM14_5340) 4704281..4704523 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
STM14_RS23325 (STM14_5341) 4704513..4704797 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STM14_RS23330 (STM14_5342) 4704801..4705265 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
STM14_RS23335 (STM14_5343) 4705386..4707524 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
STM14_RS23345 (STM14_5345) 4707933..4709585 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T26064 WP_000220578.1 NC_016856:4704513-4704797 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T26064 NC_016856:4704513-4704797 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT26064 WP_000212724.1 NC_016856:4704281-4704523 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT26064 NC_016856:4704281-4704523 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References