Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4246749..4247368 Replicon chromosome
Accession NZ_CP107291
Organism Klebsiella pneumoniae strain CRKP_45

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OH513_RS21345 Protein ID WP_002892050.1
Coordinates 4247150..4247368 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag OH513_RS21340 Protein ID WP_002892066.1
Coordinates 4246749..4247123 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH513_RS21330 4241901..4243094 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH513_RS21335 4243117..4246263 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
OH513_RS21340 4246749..4247123 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
OH513_RS21345 4247150..4247368 + 219 WP_002892050.1 HHA domain-containing protein Toxin
OH513_RS21350 4247527..4248093 + 567 WP_002892030.1 maltose O-acetyltransferase -
OH513_RS21355 4248065..4248205 - 141 WP_004147370.1 hypothetical protein -
OH513_RS21360 4248226..4248696 + 471 WP_002892026.1 YlaC family protein -
OH513_RS21365 4248671..4250122 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
OH513_RS21370 4250223..4250921 + 699 WP_002892021.1 GNAT family protein -
OH513_RS21375 4250918..4251058 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
OH513_RS21380 4251058..4251321 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260637 WP_002892050.1 NZ_CP107291:4247150-4247368 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT260637 WP_002892066.1 NZ_CP107291:4246749-4247123 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References