Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 4575390..4576171 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag STM14_RS22660 Protein ID WP_000626099.1
Coordinates 4575680..4576171 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag STM14_RS22655 Protein ID WP_001110452.1
Coordinates 4575390..4575683 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS22630 (STM14_5184) 4571714..4572619 + 906 WP_001268200.1 YjiK family protein -
STM14_RS22635 (STM14_5185) 4572913..4573182 - 270 WP_010989096.1 hypothetical protein -
STM14_RS26230 (STM14_5186) 4573190..4573405 - 216 WP_001595136.1 hypothetical protein -
STM14_RS22640 (STM14_5187) 4573428..4573715 - 288 WP_001269916.1 transcriptional regulator RtsB -
STM14_RS22645 (STM14_5188) 4573712..4574587 - 876 WP_000921674.1 AraC family transcriptional regulator -
STM14_RS22650 (STM14_5190) 4574852..4575073 - 222 WP_001576552.1 hypothetical protein -
STM14_RS22655 (STM14_5191) 4575390..4575683 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
STM14_RS22660 (STM14_5192) 4575680..4576171 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
STM14_RS22665 (STM14_5193) 4576419..4577171 - 753 WP_000842434.1 non-specific acid phosphatase -
STM14_RS26880 4577274..4577348 - 75 Protein_4336 porin family protein -
STM14_RS22670 (STM14_5194) 4578381..4578758 - 378 WP_000916345.1 EthD family reductase -
STM14_RS22675 (STM14_5195) 4578830..4579162 + 333 WP_001165471.1 MerR family transcriptional regulator -
STM14_RS25695 4579253..4579330 + 78 Protein_4339 helix-turn-helix domain-containing protein -
STM14_RS22685 (STM14_5198) 4579601..4580176 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T26063 WP_000626099.1 NC_016856:4575680-4576171 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T26063 NC_016856:4575680-4576171 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT26063 WP_001110452.1 NC_016856:4575390-4575683 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT26063 NC_016856:4575390-4575683 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References