Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1988..2535 Replicon plasmid p86
Accession NZ_CP107288
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag OF379_RS25105 Protein ID WP_013009346.1
Coordinates 2257..2535 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag OF379_RS25100 Protein ID WP_000079932.1
Coordinates 1988..2257 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS25090 (OF379_25090) 46..1077 + 1032 WP_000907881.1 plasmid replication initiator RepA -
OF379_RS25095 (OF379_25095) 1775..1933 + 159 WP_000829588.1 hypothetical protein -
OF379_RS25100 (OF379_25100) 1988..2257 + 270 WP_000079932.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
OF379_RS25105 (OF379_25105) 2257..2535 + 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
OF379_RS25110 (OF379_25110) 2731..3027 - 297 WP_001419651.1 hypothetical protein -
OF379_RS25115 (OF379_25115) 3372..3959 + 588 WP_001418189.1 serine acetyltransferase -
OF379_RS25120 (OF379_25120) 4241..4834 - 594 WP_001401779.1 ProQ/FINO family protein -
OF379_RS25125 (OF379_25125) 5188..6534 + 1347 WP_001132021.1 protein YagA -
OF379_RS25130 (OF379_25130) 7125..7427 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..86134 86134


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T260626 WP_013009346.1 NZ_CP107288:2257-2535 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT260626 WP_000079932.1 NZ_CP107288:1988-2257 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References