Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 27150..27742 | Replicon | plasmid p34 |
Accession | NZ_CP107287 | ||
Organism | Escherichia coli strain SW4848 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V0AGQ2 |
Locus tag | OF379_RS25040 | Protein ID | WP_000520549.1 |
Coordinates | 27494..27742 (-) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | V0AWG0 |
Locus tag | OF379_RS25035 | Protein ID | WP_000681613.1 |
Coordinates | 27150..27497 (-) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OF379_RS25005 (OF379_25005) | 23152..23478 | - | 327 | WP_000008644.1 | TrbC/VirB2 family protein | - |
OF379_RS25010 (OF379_25010) | 23492..24112 | - | 621 | WP_000157549.1 | lytic transglycosylase domain-containing protein | - |
OF379_RS25015 (OF379_25015) | 24469..24684 | - | 216 | WP_000760375.1 | EexN family lipoprotein | - |
OF379_RS25020 (OF379_25020) | 24681..24974 | - | 294 | WP_000134733.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
OF379_RS25025 (OF379_25025) | 25051..26280 | - | 1230 | WP_016231858.1 | DNA relaxase/nickase TaxC | - |
OF379_RS25030 (OF379_25030) | 26284..26787 | - | 504 | WP_000781814.1 | relaxosome-coupling protein TaxA | - |
OF379_RS25035 (OF379_25035) | 27150..27497 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
OF379_RS25040 (OF379_25040) | 27494..27742 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
OF379_RS25045 (OF379_25045) | 28052..28345 | - | 294 | WP_001401669.1 | hypothetical protein | - |
OF379_RS25050 (OF379_25050) | 28360..28734 | - | 375 | WP_000844303.1 | tail-associated lysozyme | - |
OF379_RS25055 (OF379_25055) | 28786..29085 | - | 300 | WP_263955274.1 | hypothetical protein | - |
OF379_RS25060 (OF379_25060) | 29539..29766 | - | 228 | WP_000801440.1 | hypothetical protein | - |
OF379_RS25065 (OF379_25065) | 29756..30004 | - | 249 | WP_001230706.1 | hypothetical protein | - |
OF379_RS25070 (OF379_25070) | 30001..30543 | - | 543 | WP_001083906.1 | hypothetical protein | - |
OF379_RS25075 (OF379_25075) | 30648..31163 | - | 516 | WP_001025395.1 | J domain-containing protein | - |
OF379_RS25080 (OF379_25080) | 31803..32153 | - | 351 | WP_000127482.1 | addiction module antitoxin | - |
OF379_RS25085 (OF379_25085) | 32150..32485 | - | 336 | WP_001147119.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..33549 | 33549 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CIX3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CLC1 |