Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4526532..4527029 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OF379_RS21865 Protein ID WP_001173343.1
Coordinates 4526532..4526705 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2X1N3L1
Locus tag OF379_RS21870 Protein ID WP_001560287.1
Coordinates 4526733..4527029 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS21855 (4523202) 4523202..4524659 + 1458 WP_000856819.1 dipeptide/tripeptide permease DtpC -
OF379_RS21860 (4524896) 4524896..4526413 + 1518 WP_000003806.1 lysine--tRNA ligase -
OF379_RS21865 (4526532) 4526532..4526705 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OF379_RS21870 (4526733) 4526733..4527029 - 297 WP_001560287.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OF379_RS21875 (4527258) 4527258..4527530 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OF379_RS21880 (4527542) 4527542..4527772 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
OF379_RS21885 (4527953) 4527953..4529584 + 1632 WP_001216477.1 sensor histidine kinase -
OF379_RS21890 (4529581) 4529581..4530300 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T260622 WP_001173343.1 NZ_CP107284:c4526705-4526532 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11441.94 Da        Isoelectric Point: 4.2924

>AT260622 WP_001560287.1 NZ_CP107284:c4527029-4526733 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMHDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1N3L1

References