260621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4424478..4425073 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag OF379_RS21345 Protein ID WP_000239581.1
Coordinates 4424478..4424828 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag OF379_RS21350 Protein ID WP_001223213.1
Coordinates 4424822..4425073 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS21325 (4419925) 4419925..4420947 - 1023 WP_001586590.1 ABC transporter permease -
OF379_RS21330 (4420961) 4420961..4422463 - 1503 WP_000210560.1 sugar ABC transporter ATP-binding protein -
OF379_RS21335 (4422603) 4422603..4423559 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OF379_RS21340 (4423869) 4423869..4424399 + 531 WP_000055075.1 inorganic diphosphatase -
OF379_RS21345 (4424478) 4424478..4424828 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
OF379_RS21350 (4424822) 4424822..4425073 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OF379_RS21355 (4425285) 4425285..4425626 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OF379_RS21360 (4425629) 4425629..4429408 - 3780 WP_000060909.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T260621 WP_000239581.1 NZ_CP107284:c4424828-4424478 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT260621 WP_001223213.1 NZ_CP107284:c4425073-4424822 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References