Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4413000..4413522 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag OF379_RS21285 Protein ID WP_001105433.1
Coordinates 4413000..4413290 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag OF379_RS21290 Protein ID WP_000212715.1
Coordinates 4413280..4413522 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS21270 (4408163) 4408163..4409818 + 1656 WP_001315166.1 alpha,alpha-phosphotrehalase -
OF379_RS21275 (4410212) 4410212..4412350 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
OF379_RS21280 (4412535) 4412535..4412999 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OF379_RS21285 (4413000) 4413000..4413290 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF379_RS21290 (4413280) 4413280..4413522 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OF379_RS21295 (4413714) 4413714..4414100 - 387 WP_001232253.1 cytochrome b562 -
OF379_RS21300 (4414283) 4414283..4415635 - 1353 WP_001162173.1 metalloprotease PmbA -
OF379_RS21305 (4415729) 4415729..4416280 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
OF379_RS21310 (4416363) 4416363..4417736 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T260620 WP_001105433.1 NZ_CP107284:c4413290-4413000 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT260620 WP_000212715.1 NZ_CP107284:c4413522-4413280 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References