Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4308652..4309466 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OF379_RS20750 Protein ID WP_001054376.1
Coordinates 4308652..4308909 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OF379_RS20755 Protein ID WP_001309181.1
Coordinates 4308921..4309466 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS20725 (4303940) 4303940..4305046 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
OF379_RS20730 (4305111) 4305111..4306091 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OF379_RS20735 (4306201) 4306201..4306406 + 206 Protein_4058 HNH endonuclease -
OF379_RS20740 (4306674) 4306674..4307914 - 1241 Protein_4059 helicase YjhR -
OF379_RS20745 (4308030) 4308030..4308161 + 132 WP_001309182.1 hypothetical protein -
OF379_RS20750 (4308652) 4308652..4308909 + 258 WP_001054376.1 YjhX family toxin Toxin
OF379_RS20755 (4308921) 4308921..4309466 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
OF379_RS20760 (4309522) 4309522..4310268 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OF379_RS20765 (4310437) 4310437..4310655 + 219 Protein_4064 hypothetical protein -
OF379_RS20770 (4310693) 4310693..4310809 + 117 Protein_4065 VOC family protein -
OF379_RS20775 (4311054) 4311054..4312175 + 1122 WP_000010829.1 M42 family metallopeptidase -
OF379_RS20780 (4312172) 4312172..4312450 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OF379_RS20785 (4312462) 4312462..4313775 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4301146..4317690 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T260619 WP_001054376.1 NZ_CP107284:4308652-4308909 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT260619 WP_001309181.1 NZ_CP107284:4308921-4309466 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References