260616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3691884..3692502 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OF379_RS17880 Protein ID WP_001291435.1
Coordinates 3692284..3692502 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OF379_RS17875 Protein ID WP_000344800.1
Coordinates 3691884..3692258 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS17865 (3686973) 3686973..3688166 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OF379_RS17870 (3688189) 3688189..3691338 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
OF379_RS17875 (3691884) 3691884..3692258 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OF379_RS17880 (3692284) 3692284..3692502 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OF379_RS17885 (3692674) 3692674..3693225 + 552 WP_000102564.1 maltose O-acetyltransferase -
OF379_RS17890 (3693341) 3693341..3693811 + 471 WP_000136192.1 YlaC family protein -
OF379_RS17895 (3693975) 3693975..3695525 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OF379_RS17900 (3695567) 3695567..3695920 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OF379_RS17910 (3696299) 3696299..3696610 + 312 WP_000409911.1 MGMT family protein -
OF379_RS17915 (3696641) 3696641..3697213 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260616 WP_001291435.1 NZ_CP107284:3692284-3692502 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT260616 WP_000344800.1 NZ_CP107284:3691884-3692258 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References