Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2410750..2412338 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name hipA Uniprot ID A0A377LF41
Locus tag OF379_RS11600 Protein ID WP_001125419.1
Coordinates 2411016..2412338 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A366Y5V8
Locus tag OF379_RS11595 Protein ID WP_001366357.1
Coordinates 2410750..2411016 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS11595 (2410750) 2410750..2411016 + 267 WP_001366357.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OF379_RS11600 (2411016) 2411016..2412338 + 1323 WP_001125419.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
OF379_RS11605 (2412489) 2412489..2413388 - 900 WP_001057775.1 LysR substrate-binding domain-containing protein -
OF379_RS11610 (2413528) 2413528..2413836 + 309 WP_001221046.1 hypothetical protein -
OF379_RS11615 (2413845) 2413845..2414534 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
OF379_RS11620 (2414608) 2414608..2415555 + 948 WP_000854795.1 aldo/keto reductase -
OF379_RS11625 (2415658) 2415658..2415813 + 156 WP_001327998.1 hypothetical protein -
OF379_RS11630 (2415773) 2415773..2416192 + 420 WP_001327999.1 amidohydrolase family protein -
OF379_RS11635 (2416182) 2416182..2416334 + 153 WP_001322417.1 amidohydrolase family protein -
OF379_RS11640 (2416485) 2416485..2417057 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49317.90 Da        Isoelectric Point: 8.8783

>T260613 WP_001125419.1 NZ_CP107284:2411016-2412338 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPNAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10077.48 Da        Isoelectric Point: 4.9632

>AT260613 WP_001366357.1 NZ_CP107284:2410750-2411016 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLMTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377LF41

Antitoxin

Source ID Structure
AlphaFold DB A0A366Y5V8

References