Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 908809..909463 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OF379_RS04320 Protein ID WP_000244777.1
Coordinates 909056..909463 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7B2N3K9
Locus tag OF379_RS04315 Protein ID WP_001604807.1
Coordinates 908809..909075 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS04290 (904092) 904092..904835 + 744 WP_001366570.1 SDR family oxidoreductase -
OF379_RS04295 (904897) 904897..906330 - 1434 WP_001604813.1 6-phospho-beta-glucosidase BglA -
OF379_RS04300 (906375) 906375..906686 + 312 WP_001604811.1 N(4)-acetylcytidine aminohydrolase -
OF379_RS04305 (906850) 906850..907509 + 660 WP_000250269.1 hemolysin III family protein -
OF379_RS04310 (907586) 907586..908566 - 981 WP_001604809.1 tRNA-modifying protein YgfZ -
OF379_RS04315 (908809) 908809..909075 + 267 WP_001604807.1 FAD assembly factor SdhE Antitoxin
OF379_RS04320 (909056) 909056..909463 + 408 WP_000244777.1 protein YgfX Toxin
OF379_RS04325 (909503) 909503..910024 - 522 WP_001055874.1 flavodoxin FldB -
OF379_RS04330 (910136) 910136..911032 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
OF379_RS04335 (911057) 911057..911767 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OF379_RS04340 (911773) 911773..913506 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T260607 WP_000244777.1 NZ_CP107284:909056-909463 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10595.21 Da        Isoelectric Point: 5.6375

>AT260607 WP_001604807.1 NZ_CP107284:908809-909075 [Escherichia coli]
MYINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7B2N3K9

References