Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 159903..160515 Replicon chromosome
Accession NZ_CP107284
Organism Escherichia coli strain SW4848

Toxin (Protein)


Gene name hicA Uniprot ID A0A167AMN3
Locus tag OF379_RS00690 Protein ID WP_000833474.1
Coordinates 159903..160088 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag OF379_RS00695 Protein ID WP_000499746.1
Coordinates 160105..160515 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF379_RS00675 (155420) 155420..156571 + 1152 WP_000741506.1 L-threonine dehydrogenase -
OF379_RS00680 (156772) 156772..158310 + 1539 WP_001469350.1 aldehyde dehydrogenase AldB -
OF379_RS00685 (158351) 158351..159430 - 1080 WP_000061479.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
OF379_RS00690 (159903) 159903..160088 + 186 WP_000833474.1 type II toxin-antitoxin system HicA family toxin Toxin
OF379_RS00695 (160105) 160105..160515 + 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OF379_RS00700 (160587) 160587..162551 - 1965 WP_001026871.1 glycoside hydrolase family 127 protein -
OF379_RS00705 (162562) 162562..163962 - 1401 WP_000204815.1 MFS transporter -
OF379_RS00710 (164188) 164188..165003 + 816 WP_000891838.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6819.94 Da        Isoelectric Point: 12.0345

>T260605 WP_000833474.1 NZ_CP107284:159903-160088 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSRHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT260605 WP_000499746.1 NZ_CP107284:160105-160515 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167AMN3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References