Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 973916..975477 Replicon chromosome
Accession NZ_CP107282
Organism Vibrio natriegens strain PWH3a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OFO16_RS04620 Protein ID WP_263838253.1
Coordinates 974173..975477 (+) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A7Y3QDE7
Locus tag OFO16_RS04615 Protein ID WP_065771554.1
Coordinates 973916..974155 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFO16_RS04595 (OFO16_04595) 969060..969251 - 192 WP_151514602.1 helix-turn-helix domain-containing protein -
OFO16_RS04600 (OFO16_04600) 969346..970518 + 1173 WP_263838252.1 hypothetical protein -
OFO16_RS04605 (OFO16_04605) 971500..971679 + 180 Protein_874 tyrosine-type recombinase/integrase -
OFO16_RS04610 (OFO16_04610) 971794..973401 + 1608 WP_258653174.1 hypothetical protein -
OFO16_RS04615 (OFO16_04615) 973916..974155 + 240 WP_065771554.1 helix-turn-helix domain-containing protein Antitoxin
OFO16_RS04620 (OFO16_04620) 974173..975477 + 1305 WP_263838253.1 type II toxin-antitoxin system HipA family toxin Toxin
OFO16_RS04625 (OFO16_04625) 975669..976991 - 1323 WP_069539743.1 site-specific integrase -
OFO16_RS04630 (OFO16_04630) 977282..978073 - 792 WP_263838254.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -
OFO16_RS04635 (OFO16_04635) 978175..979272 + 1098 WP_263838255.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(143-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-59)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 48719.88 Da        Isoelectric Point: 8.2443

>T260604 WP_263838253.1 NZ_CP107282:974173-975477 [Vibrio natriegens]
MNGVKVGVLEKRTNGAHVFTYDSGWVLAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARYKADTKQPF
DLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKTALLFYDGR
WMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDRKLSSDNSY
YLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSIAASGRYQL
APLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFESTAMEVID
SVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Download         Length: 1305 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8704.96 Da        Isoelectric Point: 7.2039

>AT260604 WP_065771554.1 NZ_CP107282:973916-974155 [Vibrio natriegens]
MLVNTPTALGNALREARKESGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3QDE7

References