260603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1927250..1927883 Replicon chromosome
Accession NZ_CP107276
Organism Weizmannia coagulans strain 150

Toxin (Protein)


Gene name mazF Uniprot ID G2TIM0
Locus tag OF848_RS09735 Protein ID WP_013860680.1
Coordinates 1927250..1927600 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G2TIL9
Locus tag OF848_RS09740 Protein ID WP_014096808.1
Coordinates 1927605..1927883 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF848_RS09700 (OF848_09700) 1922435..1923214 - 780 WP_029142785.1 RNA polymerase sigma factor SigB -
OF848_RS09705 (OF848_09705) 1923192..1923662 - 471 WP_017553287.1 anti-sigma B factor RsbW -
OF848_RS09710 (OF848_09710) 1923666..1923995 - 330 WP_013860674.1 anti-sigma factor antagonist -
OF848_RS09715 (OF848_09715) 1924064..1925074 - 1011 WP_029142786.1 PP2C family protein-serine/threonine phosphatase -
OF848_RS09720 (OF848_09720) 1925089..1925490 - 402 WP_263931224.1 anti-sigma regulatory factor -
OF848_RS09725 (OF848_09725) 1925495..1925851 - 357 WP_017553290.1 STAS domain-containing protein -
OF848_RS09730 (OF848_09730) 1925855..1926682 - 828 WP_029142788.1 RsbT co-antagonist protein RsbRA -
OF848_RS09735 (OF848_09735) 1927250..1927600 - 351 WP_013860680.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OF848_RS09740 (OF848_09740) 1927605..1927883 - 279 WP_014096808.1 hypothetical protein Antitoxin
OF848_RS09745 (OF848_09745) 1928036..1929187 - 1152 WP_029142789.1 alanine racemase -
OF848_RS09750 (OF848_09750) 1929389..1930405 - 1017 WP_013860683.1 outer membrane lipoprotein carrier protein LolA -
OF848_RS09755 (OF848_09755) 1930546..1930896 - 351 WP_029142790.1 holo-ACP synthase -
OF848_RS09760 (OF848_09760) 1931178..1931777 + 600 WP_029142791.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12968.01 Da        Isoelectric Point: 4.8998

>T260603 WP_013860680.1 NZ_CP107276:c1927600-1927250 [Weizmannia coagulans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGLERDSVILLEQI
RTIDKQRLTDKITHLDEEVMEKIDDALQISLGLVEF

Download         Length: 351 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10633.19 Da        Isoelectric Point: 5.2204

>AT260603 WP_014096808.1 NZ_CP107276:c1927883-1927605 [Weizmannia coagulans]
VSEPISTEILVRLPQQLLTELDGFAETENMNRNELIYRATKMYLKERKKRQIRETMRRGYMEMAKINLAIASEAIQAEYE
AEHTVESLVSGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4BYJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4BX66

References